Oh no, I thought I was killin it in the broke loser game but I'm so much older and I had two spontaneous social interactions with my neighbours tonight and joined a community action group
FUCK
I"VE DROPPED THE BALL
JustSo
joined 1 year ago
Yoooo I missed that the first time. Thanks for pointing it out, adding this to my masonic freemason gangsign collection.
Well shit, now I can't unsee it. How you gonna do me like this.
Wrong. A black comedian youtuber referred to my people as "aka the most useless crayon" and my dead homie would venomously spit about "pink motherfucker"s.
Both quality slurs imo. I enjoy them immensely and felt something actually hit me with the crayon comment. Like, I'm obviously not sensitive about being a cracker, but it landed hard enough that if I were the type of white to feel capable of being the victim of racism from within the imperial realm, it might have actually hurt my feelings. Could see it making a whiteboy mad as hell.
Yup. I think the concern displayed by all in this thread is valid and appropriate given what's been properly studied.
Appreciate the summary/abstract. I'm getting into the NYE spirit right now and have been posting on and off all day so my capacity to read studies and grok them is diminished.
My pharma friend is finding a fair bit of research into treatment of major depressive disorder with this daily dosing in conjunction with antidepressants. I've posted a blog link compiling findings in a comment further up the thread if you're interested.
I would trust your analysis of these sources more than my own.
Collection of papers, summarised on ketamine + Antidepressant (incl. SSRI) interaction (or lack of, I haven't done the reading. Go figure.)
https://psychedelics.ucsf.edu/blog/interactions-between-ketamine-and-prescription-antidepressants
Selective serotonin reuptake inhibitors (SSRIs)
No concerning interactions exist - clinical trials have shown ketamine’s safety and efficacy in patient populations concurrently using escitalopram and sertraline[3][4]. Combination treatment may confer synergistic effects, as demonstrated by a clinical trial comparing escitalopram + ketamine v. escitalopram + placebo for major depressive disorder (MDD), in which ketamine was found to augment the therapeutic efficacy of the SSRI with improvement in suicidality[5]. Another trial on sertraline also suggests that ketamine may be used as adjuvant therapy[6]. However, it’s important to note that ketamine is metabolized by the liver enzymes P450 CYP2B6 and CYP3A4 primarily, so any inhibitors and inducers of these enzymes could alter the metabolism of ketamine. Paroxetine, sertraline, fluoxetine, and fluvoxamine are all CYP3A4 inhibitors, so concurrent use of ketamine can possibly elevate the bioavailability of ketamine. However, this slight elevation may not be clinically significant[7][8].
FYI, a friend shared this, it links to actual papers. It sounds like the product being offered here. I haven't read enough yet to know if any of this has gone past clinical trial stages, but you are dead right that Corgi is probably entitled to receive compensation if this is a trial. Could that be the loophole and they're just counting on ignorance or some corporate / marketing construct to launder the trial / fast-track putting the formulation onto the market for a purely profit driven motive?
Friend also suggested that some of the links may be inaccurate, so I suppose further digging would be required to match paper titles with their papers in the usual databases. Obviously "osmind.org" doesn't hit with a lot of authority.
I'm sure we'll be reading about the details in the alternative press and then mainstream news within the next couple of years after a bunch of burnout casualties result from this.
Correct they should be used as an adjunct therapy to buy the patient temporary relief and the mental space to move forward while actively working to form new sustainable behavior patterns and learning skills to cope with intrusive thoughts and triggering situations.
I believe this is also true of most SSRIs but that will probably be a controversial opinion, since those drugs do not work on the correct timescales to be used effectively for that sort of treatment given the ramp-up and taper-off requirements and general roulette wheel of finding one that "works" for the patient.
Edit: And this is really the crux of why the service Corgi has found is highly suspicious. Without offering therapy, just meds, they are not on some well meaning hippocratic oath keeping mission. It's a loophole exploit.
I punk gooners. Your orgasm? Denied.