windowlicker
i love the idea of this comm! i’d volunteer as a mod if it was made
it definitely is going extremely fast lol, i feel like every week there’s something new and wild and it’s hard to keep up with.
i’ll definitely leave a comment! i’m not a healthcare provider at all and specialize more in microorganisms but i guess all life has a similar foundation, so id love to contribute.
thanks for finding the paper and summarizing it! yeah i can definitely see how this wouldn’t really be as effective as they touted, especially with the vector problem. though there are a lot of different viruses that could be used as vectors right? i knew someone who did research into parvoviruses and it seems like they could work too. i still think it’s a cool idea though and i’m hoping it finds more applications.
yes, i believe the intention here (as is outlined in the paper you linked) is to target viruses before they infect a cell for the greatest chance of preventing what you described? but again, its really unclear to me without the original paper but that link in the article isn't working which really sucks.
i'm a molecular biologist and would love to see the actual paper (because i think this article is horribly written and really doesn't explain this very well), but there exists research already for this concept. hypothetically, it would be extremely difficult for a virus to mutate to block siRNAs as they target entire essential genes, such as structural ones or essential replication proteins, so the virus would have to fundamentally change many different and important genes to evade siRNA detection, and also because in therapeutic settings, many different siRNAs targeting different sites would be used simultaneously. even in viruses that have evolved to have RNAi suppressing proteins, some research shows that synthetic siRNAs can still have an effect.
1-2. i kinda love the slight starchiness and once it starts getting a bit yellow, its perfectly firm and the banana flavor really shines through. even the green ones i'll eat from time to time.
one of the greatest bands of all time. if anyone likes this song, please listen to the rest of this album (13 songs) and their other album repeater as well!
the famously non-religious mandate of heaven
all the fallout talk got me to plug the xbox 360 back in and replay new vegas. that's all i've been playing.