I run NixOS on my Ryzen Framework 13 and it works flawlessly, including fingerprint reader. I run KDE now but I’ve also used Gnome with no issues.
I used this nixos-hardware module for some of the fancier hardware tweaks I don’t really understand: https://github.com/NixOS/nixos-hardware
if i have it on a table, it’s fine, mostly silent. if i have it on my lap blocking the vents then it can get noisier and hotter pretty fast