Survival mode in Skyrim is quite interesting as a level 81 Vampire Lord. My follower is my spouse, Uthgerd the Unbroken, now turned Vampire herself too. She can cook me a hot meal everyday we travel and I can feed off people at night (my favorite is Jarls) so I don't have to worry about hunger that much. Switching into Vampire Lord is great for travelling at night between towns, because you're immune to the severe cold and can fly over water.
I'm using a mod that lets me teleport between Volkhiar Castle, Bloodchill Manor and Gallows Hall. Which is enough to be a powerful Vampire and Mage who doesn't need to wait, but also I still have to plan quest journeys.
I'm using a powerful female vampire as a dead thrall. I like that it's either intentional or a glitch but if you reanimate certain dead vampires they have dialogue, often the same lines repeated over and over instead of groaning like humans. It's like in reanimating an already undead being, I've brought them back much further but they're still not quite right.
Lesbian Toxic Yuri, I swapped my character and Uthgard's wedding rings for the Ring of Erudite and the Ring of the Beast.