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To be honest, I admit I can't understand it, now if you understood it explain in layman's terms, now if you expound this again,
you're trying to confuse me since dopamine lang ang nandoon sa source mo sa link, and dopamine is a pleasure hormone so it could be more about pleasure and less or not about pain
im talking about in generality kaya i said taking "substance" as compare to meditation, the substance hack your receptor then your body produces hormones, in a way its like mind or bofy over matter din, kasi katawan mo pa rin mag produce ng hormones, but as i said di lahat, may mindset na ganun, so you need to take substance kaya ininclude ko na yung iban hormones and the "likes" when talking about substance that is taken.
okay if your talking about phys, pain your right, but when its about mental pain you need some happy hormones.