fermionsnotbosons

joined 2 years ago
 

I assume anyone who comes here will either have completed a reaction or studied one (computationally, in a course, for fun, etc.) recently, so why not share favorites? Include why you liked it best, if you feel like elaborating!

I'll go first.

Mine might be the reaction of an oxime (in dichloromethane) with an O-protected propargylic alcohol, using bleach and triethylamine. The oxime gets converted into a nitrile oxide by the bleach and base, and then undergoes a 3+2 cycloaddition with the alkyne to produce an isoxazole VERY cleanly. Work-up of this biphasic reaction consisted of partitioning the phases and concentrating the organics (after a weak acid wash and silica plug), resulting in publication-quality NMR data without further purification going into the next step! Very good for me as it is a key precursor that needs to be made in very large (for R&D) quantities.

It's not super fancy by any means, but I love cycloadditions, heterocycles, and reactions that are successful with minimal byproducts (don't we all?), lol.

[–] [email protected] 1 points 2 years ago (1 children)

I would have said Party Down but they went ahead and did it. I haven't seen the new episodes yet though...

[–] [email protected] 3 points 2 years ago

Thank you for doing this, now I can more effectively manage my cat community subscriptions to get the perfect ratio of cat to everything else!

[–] [email protected] 5 points 2 years ago (2 children)

Why does nba.com list J. Hood-Schifino at 6-4 but then in their analysis call him a 'big point guard, standing at 6-foot-6'? Weak. Anyway, I am not sure about the pick considering that the Lakers need to get better ASAP. Seems like a pick for the post-Lebron future, I guess.

[–] [email protected] 3 points 2 years ago

Gila! Gila!

I heard Gila Monster and Dragon as singles already, of course. I was impressed with both - maybe Dragon wins by a snout for the more interesting (IMO) guitar riffs, and the syncopation between those and the drums/bass is pretty cool. The overall style being less thrash and more prog sounding than Gila Monster makes me favor it a bit more as well. Gila Monster sounds like it could have been made by Ride the Lightning or Master of Puppets era Metallica - if they took themselves a little less seriously - which is very badass too.

I will listen to the album all the way through tonight and report back!

[–] [email protected] 1 points 2 years ago

I definitely will! I already subscribed to it a day or two ago (still pending, I guess). Thanks for the reminder to visit anyway!

[–] [email protected] 3 points 2 years ago

I am pretty sure I saw a homelab community on lemmy.ml already, just FYI.

[–] [email protected] 1 points 2 years ago

Cat regret, lol.

 

Woke him up from nap #6 that day.

[–] [email protected] 1 points 2 years ago

Final Fantasy IV (released as FFII in North America) is my favorite of all time, just gorgeous. Shout out to Tony Hawk Pro Skater 4 as well, for bringing a nice mix of rock and hip-hop subgenres into our homes.

 

She hears the crinkling sound of the paper bag and comes running from the other room.

[–] [email protected] 1 points 2 years ago (2 children)

On book 9 (Winter's Heart) of the Wheel of Time right now, albeit for the 4th time! If it's your first read of the series I hope you're enjoying it, it's my favorite of all time. Book 11 is one of the very best!

I also just started The Prince of Nothing series, for which I've heard good things. I'll have more to say about it later.

[–] [email protected] 1 points 2 years ago

IMO, yes, it was a good first season with some flaws that will hopefully be improved upon just like the first book was good (not great) and definitely improved upon by subsequent entries.

I've read the series 3 times, and am on my 4th read (book 9) right now. Having re-read book 1 in 2019, I had a pretty clear memory of it when the show premiered and was glad to see some repetitive and inconsistent content from book 1 cut and replaced with more integral subject matter (e.g., the warder bond).

Overall, I am most happy to see the world and characters introduced to a larger audience, who seem to be finding the books in the lull between seasons. I also typically give adaptations plenty of leeway to tell the story in a way that works for the new medium. I am psyched to see how they did with season 2.

[–] [email protected] 1 points 2 years ago

Playing a bunch of online Diplomacy. And I got back into Skyrim recently, although half that time is spent researching and installing new mods, of course.

view more: next ›