I used WineASIO with Guitar Rig for a long time and it worked well and with acceptably low latency. It can be a hassle to set up though and I don't know how it plays along with pipewire these days.
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There's a long list of supported controllers. The process for making your own mappings can indeed be a bit cumbersome, but it also seems to be quite powerful in the kind of features it can support, thanks to javascript integration.
Not sure about the library management, seems to work well enough for me.