Death and "decay" right? The little dust motes, the stray sock on your chair, the mold in your shower, the grey hair on your head, the new wrinkle near your eye, the new ache in your knee, the yellowing family photos, the moment when you can't quite remember your nephews name.
The little things that fall apart until that one day you just... stop.
I'm playing Last Spell right now, isometric base defense game. Lots of viable ways to play, but later missions become a slog if you don't plan out hero builds. A run takes 5-10 hours, but rounds take 20 minutes. Emphasis on crowd control and positioning.
Darkest Dungeon is nice if you want a break from isometric stuff, dungeon crawler, emphasis on team combat and resource management.
Creeper World III if you want to try RTS style, lots of community maps.
Tactical Breach Wizards, Come in through a window, throw everyone else out the window. Silly, but fun.