No, you won’t regret it unless you sell pedals that are niche or hard to come by again. Definitely keep your fuzzes.
Helix has a ton of great FX and the quality of most are nearly indiscernible form their pedal counterparts. The fuzz in all modelers isn’t quite right in my experience. I’ve got an HX Stomp (had the older Fractal floor unit before that) and I have kept my favorite pedals and a couple of niche or rare-ish pedals not in the Helix library. I’ve sold off the majority of my pedals.
After 6-7 years into my modeling journey (had a Fractal AX8 before the Helix), I am now into a less is more mindset. I still prefer a real amp with as few pedals as possible. I own amps that don’t need additional drives, EQs, or boosts. They either have a great built-in attenuator or a usable sweep in the master volume for bedroom use. 99% of the time I’m going guitar->amp these days. For that reason, I’ve only fired up the Stomp for updates. I don’t want to fiddle with things. I just want to play.
If you’re stepping all over your cables, there isn’t much of a point in spending a ton of money on cables since you’re probably going to go through them anyways. Something from Horizon should work just fine and they’re not super expensive.
I’ve picked up Boss cables from Musicians Friend’s “Stupid Deal of the Day” and they have been great.
I had problems over the years with D’Addario’s Classic and Custom series. It’s almost like plugs are a hair too short and don’t always properly lock in place in my guitars (especially my Teles) and certain pedals. However, their American Stage cables are fantastic, albeit pricey.
Going wireless might be an option, too. Over the long run it might wind up being cheaper.