British No. 1 Emma Raducanu and Wimbledon champion Carlos Alcaraz will team up for the new-look US Open mixed doubles event in August, hoping to secure the $1 million prize on offer.
Former US Open winner Naomi Osaka will team up with Nick Kyrgios, while Britain's Jack Draper will play alongside Chinese world No. 4 Zheng Qinwen.
Superstars Novak Djokovic - due to play with compatriot Olga Danilovic - and Jannik Sinner, paired with American Emma Navarro, are also on the list, with this new schedule effectively seeing the tournament become a three-week event.
World No. 1 Aryna Sabalenka will partner Grigor Dimitrov, while five-time major winner Iga Swiatek will play alongside Casper Ruud.
United States Tennis Association CEO and executive director Lew Sherr said: "Seeing the teams that have already put their names on the entry list makes us all incredibly excited.
Italian pair Sara Errani and Andrea Vavassori, winners of last year's US Open mixed doubles title, initially described the decision as a "profound injustice". But they are on the entry list for the event.