The 3 vaccines from the USA chosen for Project NextGen are:

Gritstone Bio’s self-amplifying mRNA vaccine aiming to be “variant-proof”;

Covi-Vac/CoviLiv: A live virus intranasal vaccine from Codagenix; and

Castlevax viral vector intranasal vaccine, from a Mount Sinai Hospital spin-off.

Mucosal vaccines:

Mucosal vaccines are currently authorized for use in 6 countries: China, India, Indonesia, Iran, Morocco, and Russia. There are 5 of these vaccines: China has 2, and one of them is authorized in 3 countries:

Ad5-nCoV (Convidecia Air) Viral vector (adenovirus) vaccine by by CanSino (China)

BBV154 (iNCOVACC) Viral vector (adenovirus) intranasal vaccine by Bharat Biotech (India), using ChAd-SARS-CoV-2-S by Washington University in St Louis

DNS1-RBD (Pneucolin) viral vector intranasal vaccine, by Beijing Wantai BioPharm (China)

Razi Cov Pars Protein subunit by Razi Vaccine & Serum Research Institute (Iran)

27 have reached clinical trial, with at least one of those has been discontinued.

6 mucosal vaccines have reached phase 3 trials, including the 5 authorized vaccines.

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[–] [email protected] 5 points 2 years ago

When can I get these in my lungs 👄🫁

[–] [email protected] 4 points 2 years ago

A new study just came out showing progress on a mucosal vaccine.

An exciting development for a new Covid vaccine: inhaled single dose induces strong mucosal immunity and protection in multiple species, including non-human primates, and prevents transmission across all variants assessed It's a dry powder for aerosol that does not have a cold chain requirement, big practical advantage

https://nitter.net/EricTopol/status/1734971879512027542#m

The vaccine encapsulates assembled nanoparticles comprising proteinaceous cholera toxin B subunits displaying the SARS-CoV-2 RBD antigen within microcapsules of optimal aerodynamic size, and this unique nano–micro coupled structure supports efficient alveoli delivery, sustained antigen release and antigen-presenting cell uptake, which are favourable features for the induction of immune responses.

https://www.nature.com/articles/s41586-023-06809-8