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What are your hidden gem medications/drugs/substances and what makes them ideal for your usecase (lemmy.world)

submitted 2 years ago* (last edited 2 years ago) by [email protected] to c/[email protected]

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If you notice an improperly formatted reply, kindly message the poster and gently remind them it needs to comport with the Naltrexone example below. It is simple and keeps things traversable and useful, thanks 🙏

Naltrexone

I will start with naltrexone, which can help people who have difficulty regulating their drinking have a more natural and sustainable relationship with alcohol should they choose to not cut it out of their lives entirely.

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[–] [email protected] 6 points 2 years ago (7 children)

A fun hack for melatonin is that smaller doses work better than larger doses.

[–] [email protected] 4 points 2 years ago (6 children)

Yes! Scientific trials have shown that for most people, 0.3mg of melatonin gives better quality of sleep than 3mg.

I've seen pills as high as 10mg on the shelf and have to wonder wtf they're for. If you take too much your body becomes less sensitive to it and you become dependent on supplementation. 10mg is definitely too much.

[–] [email protected] 0 points 2 years ago (2 children)

Yep, this seems to the magic number; I shudder when I hear people taking like 5-10mg. How can that be safe unless most of it is destroyed via digestion

[–] [email protected] 3 points 2 years ago (1 children)

Since it's a natural hormone the body already has ways to get rid of it. It has a half-life of less than an hour. The lethal dose is so high we haven't been able to intentionally kill animals with it: "Melatonin is not fatal even at a dose of 800 mg/kg in animal studies".

The big risk of ongoing high doses is becoming so dependent on it that you wake up as soon as it wears off (e.g. after only 4 hours of sleep). At this level you basically can't sleep without it and have to slowly wean yourself off to get back to normality.

[–] [email protected] 1 points 2 years ago

I found my dreams were extremely vivid and often extra-disturbing when my dose was high to the extent Im implying. Also, because it was so vivid and palpable, I just didnt feel rested cuz I was so engaged/engrossed by it

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