this post was submitted on 01 Jun 2025
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ADHD
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NAC - N-acetyl-cysteine. Psychiatrist recommended it for weaning myself off a THC dependency, but after reading a few PubMed-available research papers I found data supporting further research into its effects on ADHD.
Additionally, I kept researching in an attempt to improve brain fog and sleep issues I suspect are from long COVID. I found studies indicating NAC combined with guanfacine may help those symptoms.
I've found better results from 600mg NAC (standard daily dose is 1200mg) taken three times a day, and started 1mg guanfacine twice a day recently with plans to increase to 2mg twice a day in a week or two.
I would love to share the NIH papers with anyone interested. Educating yourself about your condition and its particular manifestation will get you far with an invested care team. I'm headed to bed bit will reply to any and every person interested in the research tomorrow morning.
The message I sent to my psych two days after she recommended NAC contained inline citations referring to the papers I had linked at the bottom. That due diligence communicated my dedication not only to my own care, but also to my dedication and respect for knowledge.
Don't take random supplements recommended to you on the internet. Discuss their use with a doctor or, barring that, ground your decisions in science.
Doesn't seem to be that much evidence, but I'm in the mood for a new supplement obsession - on it!
I looked back through my NIH history and you're right about the sparse evidence for ADHD, actually. Looks like my interest in NAC, in addition to weaning off THC, came from the bipolar and autism angle, its ability to act a a lead chelator, as well as some tentative dots I connected between its glutamatergic effects and some reading into a mutation of the MC1R gene as passed down to me by my red-head mother.
Likely also conflated my more recent readings into the guanfacine+NAC combo for my brain fog and sleep issues and misremembered my findings from the initial research. Good catch, and an excellent example of 'don't listen to the internet dude.'
Here are some starting points
NAC https://pmc.ncbi.nlm.nih.gov/articles/PMC8211525 - NAC review
https://www.sciencedirect.com/science/article/pii/S0149763415001190
https://pubmed.ncbi.nlm.nih.gov/35316513/
NAC+Guanfacine https://pmc.ncbi.nlm.nih.gov/articles/PMC10960163