this post was submitted on 22 May 2025
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ADHD
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This is really interesting. As I was reading the article I was wondering how they were going to wring money out of it, as amlodipine is off patent. Then I got to this part:
Classic big pharma. Slightly tweak an existing drug in an insignificant way so that you can get a new patent on it and charge exorbitant prices.
There’s no reason to believe those changes aren’t needed to work more effectively though, especially if it’s trying to be classified as an ADHD medication. Changing one molecule really can fundamentally change a drug, if it’s the right molecule changed the right way, it’s not inherently a cash grab, there’s not enough info here about the chemistry and its applications to make that call
This is correct. Amlodipine is very effective as a blood pressure medication, but it doesn't get through the blood-brain barrier which is one of the biggest hurdles for any psychiatric or neurologic medication. There's an entire special sub-type of brain cells that control what actually makes it out of the blood and to the neurons and getting things past that barrier is quite difficult.